AGP/CBH/HSA
Protein Based Chiral Columns from Daicel
Columns packed with the immobilized protein stationary phases (PSPs) are successfully utilized by scientists for separation and characterization of chiral compounds in a great number of applications, ranging from drug discovery and quality assurance of marketed drugs to environmental monitoring.
The chiral selector for the CHIRALPAK AGP is α1-acid glycoprotein (AGP), while human serum albumin (HSA) is the chiral selector for CHIRALPAK HSA. The chiral selector for CHIRALPAK CBH is cellobiohydrolase, a stable enzyme. The three chiral selectors are immobilized on 5-µm spherical silica particles. The PSPs function entirely in the reversed-phase chromatographic mode, using buffers with low organic modifier content and at moderate pH values. Enantioselectivity can easily be controlled or improved by changes in the mobile phase composition: pH, buffer and organic modifier types and concentrations.
All PSP selectors are packed in columns with 3, 4 and 10 mm internal diameter to cover separations on both analytical and semi-preparative scales.
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- Features
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CHIRALPAK AGP
- Chiral selector is alpha1-acid glycoprotein
- Separates enantiomers of an extremely broad range of drug compounds including amines, acids, amides, esters, alchohols and sulfoxides
CHIRALPAK CBH
- Chiral selector is cellobiohydrolase
- Separation of enantiomers of basic drugs from many compound classes
- Separates preferentially compounds containing one or more basic nitrogen's together with one or more hydrogen accepting or hydrogen donating groups (alcohol, phenol, carbonyl, amide, ether, sulphoxide, ester)
CHIRALPAK HSA
- Chiral selector is human serum albumin
- Especially suited for the separation of weak and strong acids, zwitterionic and nonprotolytic compounds
- Literature
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Daicel Chiral Column Catalogue
Full range of Daicel Chiral HPLC columns and applications
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